Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Breast cancer risk after salpingo-oophorectomy in healthy BRCA1/2 mutation carriers: revisiting the evidence for risk reduction.

Journal of the National Cancer Institute - 1 May 2015

Heemskerk-Gerritsen B A M, Seynaeve C, van Asperen C J, Ausems M G E M, Collée J M, van Doorn H C, Gomez Garcia E B, Kets C M, van Leeuwen F E, Meijers-Heijboer H E J, Mourits M J E, van Os T A M, Vasen H F A, Verhoef S, Rookus M A, Hooning M J

Abstract excerpt

BACKGROUND: Previous studies have reported a breast cancer (BC) risk reduction of approximately 50% after risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 mutation carriers, but may have been subject to several types of bias. The purpose of this nationwide cohort study was to assess potential bias in the estimated BC risk reduction after RRSO. METHODS: We selected BRCA1/2 mutation carriers from an ongoing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Netherlands

Share to Ovariectomy

Share to Proportional Hazards Models

Share to Receptors, Estrogen

Share to Risk Reduction Behavior

Share to Salpingectomy

Source

Identifiers

PMID: 25788320
DOI: 10.1093/jnci/djv033

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Breast cancer risk after salpingo-oophorectomy in healthy BRCA1/2 mutation carriers: revisiting the evidence for risk reduction.PMID 25788320Read ↗

Risk-reducing salpingo-oophorectomy and breast cancer risk in BRCA1 or BRCA2 mutation carriers: A systematic review and meta-analysis.Semantic proximity Read ↗

Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

Breast Cancer Incidence After Risk-Reducing Salpingo-Oophorectomy in BRCA1 and BRCA2 Mutation Carriers.Semantic proximity Read ↗

Risk-reducing bilateral salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

Association of Risk-Reducing Salpingo-Oophorectomy With Breast Cancer Risk in Women With BRCA1 and BRCA2 Pathogenic Variants.Semantic proximity Read ↗

Bilateral Salpingo-oophorectomy and Breast Cancer Risk for BRCA1 and BRCA2 Mutation Carriers: Assessing the Evidence.Semantic proximity Read ↗

Breast cancer risk and hormone replacement therapy among BRCA carriers after risk-reducing salpingo-oophorectomy.Semantic proximity Read ↗

Risk reducing Salpingo-Oophorectomy in Patients with gBRCA-mutated Breast CancerSemantic proximity Read ↗

Risk-Reducing Oophorectomy and Breast Cancer Risk Across the Spectrum of Familial Risk.Semantic proximity Read ↗

Retrospective evaluation of risk-reducing salpingo-oophorectomy for BRCA1/2 pathogenic variant carriers among a cohort study in a single institution.Semantic proximity Read ↗

Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality.Semantic proximity Read ↗

Risk-reducing mastectomy and salpingo-oophorectomy in women with hereditary breast and ovarian cancer: a single-institute experience following coverage by Japanese national medical insurance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.