Article
Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers.
Breast cancer research : BCR - 16 Jan 2020
Mavaddat Nasim, Antoniou Antonis C, Mooij Thea M, Hooning Maartje J, Heemskerk-Gerritsen Bernadette A, Noguès Catherine, Gauthier-Villars Marion, Caron Olivier, Gesta Paul, Pujol Pascal, Lortholary Alain, Barrowdale Daniel, Frost Debra, Evans D Gareth, Izatt Louise, Adlard Julian, Eeles Ros, Brewer Carole, Tischkowitz Marc, Henderson Alex, Cook Jackie, Eccles Diana, van Engelen Klaartje, Mourits Marian J E, Ausems Margreet G E M, Koppert Linetta B, Hopper John L, John Esther M, Chung Wendy K, Andrulis Irene L, Daly Mary B, Buys Saundra S, Benitez Javier, Caldes Trinidad, Jakubowska Anna, Simard Jacques, Singer Christian F, Tan Yen, Olah Edith, Navratilova Marie, Foretova Lenka, Gerdes Anne-Marie, Roos-Blom Marie-José, Van Leeuwen Flora E, Arver Brita, Olsson Håkan, Schmutzler Rita K, Engel Christoph, Kast Karin, Phillips Kelly-Anne, Terry Mary Beth, Milne Roger L, Goldgar David E, Rookus Matti A, Andrieu Nadine, Easton Douglas F
Abstract excerpt
BACKGROUND: The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be substantially biased. Prospective studies have had limited power, particularly for BRCA2 mutation carriers. Further, previous studies have not considered the effect of RRSO in the context of natural...
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