Article
Risk-Reducing Oophorectomy and Breast Cancer Risk Across the Spectrum of Familial Risk.
Journal of the National Cancer Institute - 1 Mar 2019
Terry Mary Beth, Daly Mary B, Phillips Kelly Anne, Ma Xinran, Zeinomar Nur, Leoce Nicole, Dite Gillian S, MacInnis Robert J, Chung Wendy K, Knight Julia A, Southey Melissa C, Milne Roger L, Goldgar David, Giles Graham G, Weideman Prue C, Glendon Gord, Buchsbaum Richard, Andrulis Irene L, John Esther M, Buys Saundra S, Hopper John L
Abstract excerpt
There remains debate about whether risk-reducing salpingo-oophorectomy (RRSO), which reduces ovarian cancer risk, also reduces breast cancer risk. We examined the association between RRSO and breast cancer risk using a prospective cohort of 17 917 women unaffected with breast cancer at baseline (7.2% known carriers of BRCA1 or BRCA2 mutations). During a median follow-up of 10.7 years, 1046 women were diagnosed...
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