Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification.

Abstract excerpt

BACKGROUND: Traditional classification of diffuse infiltrating gliomas (DIGs) as World Health Organization (WHO) grades II-IV is based on histological features of a heterogeneous population of tumors with varying prognoses and treatments. Over the last decade, research efforts have resulted in a better understanding of the molecular basis of glioma formation as well as the genetic alterations commonly identified...

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