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Article

KRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients.

British journal of cancer - 15 Mar 2011

Knijn N, Mekenkamp L J M, Klomp M, Vink-Börger M E, Tol J, Teerenstra S, Meijer J W R, Tebar M, Riemersma S, van Krieken J H J M, Punt C J A, Nagtegaal I D

Abstract excerpt

BACKGROUND: KRAS mutation is a negative predictive factor for treatment with anti-epidermal growth factor receptor antibody in metastatic colorectal cancer (CRC). KRAS mutation analysis is usually performed on primary tumour tissue because metastatic tissue is often not available. However, controversial data are available on the concordance of test results between primary tumours and corresponding metastases. We...

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Identifiers

PMID: 21364579
DOI: 10.1038/bjc.2011.26
PMCID: PMC3065268

Genes

KRAS

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