Article
Discordance in RAS mutations between primary colon tumor and metastases: a real event or a matter of methodology?
The International journal of biological markers - 31 Oct 2017
De Stefano Alfonso, Rosanova Mario, Malapelle Umberto, Martini Maurizio, De Falco Stefano, Attademo Laura, Fiore Giovanni, Cenci Tonia, Bellevicine Claudio, De Placido Sabino, Troncone Giancarlo, Carlomagno Chiara
Abstract excerpt
BACKGROUND: Analysis of K- and N-RAS mutations is mandatory before planning treatment of metastatic colorectal cancer, because only RAS wild-type (WT) patients can benefit from treatment with anti-EGFR monoclonal antibodies (cetuximab and panitumumab). CASE REPORT: Here we report the case of a 69-year-old male patient affected by metastatic sigmoid cancer. He underwent left hemicolectomy, and histology diagnosed...
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