High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice.

doi:10.1634/theoncologist.2008-0181

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Article

High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice.

The oncologist - 1 Dec 2008

Santini Daniele, Loupakis Fotios, Vincenzi Bruno, Floriani Irene, Stasi Irene, Canestrari Emanuele, Rulli Eliana, Maltese Paolo Enrico, Andreoni Francesca, Masi Gianluca, Graziano Francesco, Baldi Giacomo Giulio, Salvatore Lisa, Russo Antonio, Perrone Giuseppe, Tommasino Maria Rosa, Magnani Mauro, Falcone Alfredo, Tonini Giuseppe, Ruzzo Annamaria

Abstract excerpt

PURPOSE: Several studies have suggested that KRAS somatic mutations may predict resistance to cetuximab- and panitumumab-based treatments in metastatic colorectal cancer (CRC) patients. Nevertheless, most experiences were conducted on samples from primaries. The aim of this study was to evaluate the grade of concordance in terms of KRAS status between primaries and related metastases. PATIENTS AND METHODS: We...

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PMID: 19056857
DOI: 10.1634/theoncologist.2008-0181

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KRAS

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