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Article

Heterogeneity of KRAS status may explain the subset of discordant KRAS status between primary and metastatic colorectal cancer.

Diseases of the colon and rectum - 1 Sept 2011

Watanabe Toshiaki, Kobunai Takashi, Yamamoto Yoko, Matsuda Keiji, Ishihara Soichiro, Nozawa Keijiro, Iinuma Hisae, Shibuya Hajime, Eshima Kiyoshi

Abstract excerpt

BACKGROUND: KRAS status is a useful predictive marker for anti-epidermal growth factor receptor antibody therapy. OBJECTIVE: This study aimed to examine the concordance rate of KRAS mutation status between corresponding primary and metastatic colorectal cancer lesions, and also among multiple metastatic tumors. Furthermore, we examined the heterogeneity of KRAS mutations with respect to discordant KRAS status...

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PMID: 21825899
DOI: 10.1097/DCR.0b013e31821d37a3

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KRAS

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