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Article

KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: biological and clinical implications.

Annals of surgical oncology - 1 May 2010

Italiano Antoine, Hostein Isabelle, Soubeyran Isabelle, Fabas Thibault, Benchimol Daniel, Evrard Serge, Gugenheim Jean, Becouarn Yves, Brunet René, Fonck Marianne, François Eric, Saint-Paul Marie-Christine, Pedeutour Florence

Abstract excerpt

BACKGROUND: KRAS and BRAF mutations in primary colorectal tumors (PT) are predictive of nonresponse to anti-epidermal growth factor receptor (EGFR) antibodies in patients with metastatic colorectal cancer (mCRC). The question of primary resistance to anti-EGFR treatment as a result of the presenc...

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Source

Identifiers

PMID: 20049644
DOI: 10.1245/s10434-009-0864-z

Genes

BRAF
KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20049644-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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