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Article

Degraded DNA may induce discordance of KRAS status between primary colorectal cancer and corresponding liver metastases.

International journal of clinical oncology - 1 Feb 2014

Kaneko Yuka, Kuramochi Hidekazu, Nakajima Go, Inoue Yuji, Yamamoto Masakazu

Abstract excerpt

BACKGROUND: KRAS mutation is widely accepted as a strong, negative predictive marker for anti-epidermal growth factor receptor antibodies, including cetuximab and panitumumab. Previous reports demonstrated approximately 100 % concordance of KRAS status between primary colorectal cancer and liver metastases; however, mismatched KRAS status still occurs. METHODS: KRAS status was evaluated in 105 pairs of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23299277
DOI: 10.1007/s10147-012-0507-4

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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