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Article

Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathways

13 Jul 2018

Abstract excerpt

Altered DNA methylation events contribute to the pathogenesis and progression of metabolic disorders, including nonalcoholic fatty liver disease (NAFLD). Investigations of global DNA methylation patterns in liver biopsies representing severe NAFLD fibrosis have been limited. We used the HumanMethylation 450K BeadChip to analyze genome-wide methylation in patients with biopsy-proven grade 3/4 NAFLD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30005700
DOI: 10.1186/s13148-018-0525-9

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