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Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD

5 Aug 2021

Abstract excerpt

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is characterized by changes in cell composition that occur throughout disease pathogenesis, which includes the development of fibrosis in a subset of patients. DNA methylation (DNAm) is a plausible mechanism underlying these shifts, considering that DNAm profiles differ across tissues and cell types, and DNAm may play a role in cell-type...

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Share to Epigenetics and DNA Methylation
Share to Genetic Associations and Epidemiology
Share to Liver Disease Diagnosis and Treatment

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PMID: 34353365
DOI: 10.1186/s13148-021-01129-y

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