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Article

Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3' splice sites.

RNA biology - 1 Dec 2025

Herbert Austin, Hatfield Abigail, Randazza Alexandra, Miyamoto Valeria, Palmer Katie, Lackey Lela

Abstract excerpt

SF3B1 is a core component of the spliceosome involved in branch point recognition and 3' splice site selection. The SF3B1 K700E mutation (lysine to glutamic acid) is common in myelodysplastic syndrome and other blood disorders. SF3B1 K700E mutants utilize novel cryptic 3' splice sites; however, the properties distinguishing SF3B1-sensitive splice junctions from other alternatively spliced junctions are unknown....

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Source

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Identifiers

PMID: 41058062
DOI: 10.1080/15476286.2025.2570043
PMCID: PMC12520072

Genes

SF3B1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Research trail→

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Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3' splice sites.PMID 41058062Read ↗

Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3’ splice sitesSemantic proximity Read ↗

Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures.Semantic proximity Read ↗

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