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Article

A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia.

PloS one - 1 Jan 2015

Matsuno Hitomi, Ohi Kazutaka, Hashimoto Ryota, Yamamori Hidenaga, Yasuda Yuka, Fujimoto Michiko, Yano-Umeda Satomi, Saneyoshi Takeo, Takeda Masatoshi, Hayashi Yasunori

Abstract excerpt

Hypofunction of the N-methyl-D-aspartate type glutamate receptor (NMDAR) has been implicated in the pathogenesis of schizophrenia. Here, we investigated the significance of a common human genetic variation of the NMDAR NR3B subunit that inserts 4 bases within the coding region (insCGTT) in the pathogenesis of schizophrenia. The cDNA carrying this polymorphism generates a truncated protein, which is...

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Identifiers

PMID: 25768306
DOI: 10.1371/journal.pone.0116319
PMCID: PMC4358936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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