Article
Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia.
Molecular psychiatry - 1 Nov 2013
Weickert C S, Fung S J, Catts V S, Schofield P R, Allen K M, Moore L T, Newell K A, Pellen D, Huang X-F, Catts S V, Weickert T W
Abstract excerpt
Blockade of N-methyl-D-aspartate receptors (NMDARs) produces behavior in healthy people that is similar to the psychotic symptoms and cognitive deficits of schizophrenia and can exacerbate symptoms in people with schizophrenia. However, an endogenous brain disruption of NMDARs has not been clearly established in schizophrenia. We measured mRNA transcripts for five NMDAR subunit mRNAs and protein for the NR1...
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