Article

Synaptic and intrinsic mechanisms impair reticular thalamus and thalamocortical neuron function in a Dravet syndrome mouse model

2021-09-06

Abstract excerpt

<h4>ABSTRACT</h4> Thalamocortical network dysfunction contributes to seizures and sleep deficits in Dravet syndrome (DS), an infantile epileptic encephalopathy, but the underlying molecular and cellular mechanisms remain elusive. DS is primarily caused by mutations in the SCN1A gene encoding the voltage-gated sodium channel Na V 1.1, which is highly expressed in GABAergic reticular thalamus (nRT) neurons as wel...

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Literature Corpus work: aebca863-550f-5e66-9d4a-7e01ecf2bb44
DOI: 10.1101/2021.09.03.458635

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