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Article

The relationship between the val158met catechol-O-methyltransferase (COMT) polymorphism and irritable bowel syndrome.

PloS one - 18 Mar 2011

Karling Pontus, Danielsson Åke, Wikgren Mikael, Söderström Ingegerd, Del-Favero Jurgen, Adolfsson Rolf, Norrback Karl-Fredrik

Abstract excerpt

BACKGROUND: The catechol-O-methyltransferase (COMT) enzyme has a key function in the degradation of catecholamines and a functional polymorphism is val158met. The val/val genotype results in a three to fourfold higher enzymatic activity compared with the met/met genotype, with the val/met genotype exhibiting intermediate activity. Since pain syndromes as well as anxiety and depression are associated to low and...

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Source

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Identifiers

PMID: 21437260
DOI: 10.1371/journal.pone.0018035
PMCID: PMC3060919

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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