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Article

Degradation of SAMHD1 by Vpx Is Independent of Uncoating.

Journal of virology - 1 May 2015

Jáuregui Paula, Logue Eric C, Schultz Megan L, Fung Stephanie, Landau Nathaniel R

Abstract excerpt

UNLABELLED: Sterile alpha motif domain and HD domain-containing protein 1 (SAMHD1) restricts human immunodeficiency virus type 1 (HIV-1) replication in myeloid and resting T cells. Lentiviruses such as HIV-2 and some simian immunodeficiency viruses (SIVs) counteract the restriction by encoding Vpx or Vpr, accessory proteins that are packaged in virions and which, upon entry of the virus into the cytoplasm, induce...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25762741
DOI: 10.1128/JVI.03575-14
PMCID: PMC4442547

Genes

SAMHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Degradation of SAMHD1 by Vpx Is Independent of Uncoating.PMID 25762741Read ↗

Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation.Semantic proximity Read ↗

Functional analysis of the relationship between Vpx and the restriction factor SAMHD1.Semantic proximity Read ↗

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac.Semantic proximity Read ↗

Identification and characterization of naturally occurring splice variants of SAMHD1.Semantic proximity Read ↗

SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx ProteinSemantic proximity Read ↗

HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4DCAF1Semantic proximity Read ↗

Restriction of diverse retroviruses by SAMHD1Semantic proximity Read ↗

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cellsSemantic proximity Read ↗

Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hostsSemantic proximity Read ↗

Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1Semantic proximity Read ↗

SAMHD1 Impairs HIV-1 Gene Expression and Reactivation of Viral Latency in CD4 <sup>+</sup> T-cellsSemantic proximity Read ↗

SAMHD1: a new insight into HIV-1 restriction in myeloid cellsSemantic proximity Read ↗

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