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Article

Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation.

PloS one - 1 Jan 2013

Guo Haoran, Wei Wei, Wei Zhenhong, Liu Xianjun, Evans Sean L, Yang Weiming, Wang Hong, Guo Ying, Zhao Ke, Zhou Jian-Ying, Yu Xiao-Fang

Abstract excerpt

The sterile alpha motif (SAM) and HD domain-containing protein-1 (SAMHD1) inhibits the infection of resting CD4+ T cells and myeloid cells by human and related simian immunodeficiency viruses (HIV and SIV). Vpx inactivates SAMHD1 by promoting its proteasome-dependent degradation through an interaction with CRL4 (DCAF1) E3 ubiquitin ligase and the C-terminal region of SAMHD1. However, the determinants in SAMHD1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23874389
DOI: 10.1371/journal.pone.0066201
PMCID: PMC3708934

Genes

SAMHD1
DCAF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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