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Article

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac.

Retrovirology - 12 Jun 2012

Brandariz-Nuñez Alberto, Valle-Casuso Jose Carlos, White Tommy E, Laguette Nadine, Benkirane Monsef, Brojatsch Jurgen, Diaz-Griffero Felipe

Abstract excerpt

BACKGROUND: SAMHD1 is a nuclear protein that blocks lentiviral infection before reverse transcription in macrophages and dendritic cells. The viral accessory protein Vpx overcomes the SAMHD1-mediated lentiviral block by inducing its proteasomal degradation. RESULTS: Here, we identified the nuclear localization signal (NLS) of SAMHD1, and studied its contribution to restriction of HIV-1 and SIVmac. By studying the...

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Share to Acquired Immunodeficiency Syndrome
Share to Monomeric GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Localization Signals

Share to Reverse Transcription

Share to SAM Domain and HD Domain-Containing Protein 1

Share to Simian Immunodeficiency Virus

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Share to Viral Regulatory and Accessory Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22691373
DOI: 10.1186/1742-4690-9-49
PMCID: PMC3410799

Genes

SAMHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac.PMID 22691373Read ↗

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The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.Semantic proximity Read ↗

Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1Semantic proximity Read ↗

Identification and characterization of naturally occurring splice variants of SAMHD1.Semantic proximity Read ↗

SAMHD1: a new insight into HIV-1 restriction in myeloid cellsSemantic proximity Read ↗

Requirement of an additional Sam68 domain for inhibition of human immunodeficiency virus type 1 replication by Sam68 dominant negative mutants lacking the nuclear localization signal.Semantic proximity Read ↗

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cellsSemantic proximity Read ↗

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Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1Semantic proximity Read ↗

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