Article
Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle.
American journal of physiology. Renal physiology - 15 May 2015
Yoshiyama Mitsuharu, Mochizuki Tsutomu, Nakagomi Hiroshi, Miyamoto Tatsuya, Kira Satoru, Mizumachi Ryoji, Sokabe Takaaki, Takayama Yasunori, Tominaga Makoto, Takeda Masayuki
Abstract excerpt
The present study used a dual analysis of voiding behavior and reflex micturition to examine lower urinary tract function in transient receptor potential vanilloid (TRPV)1 knockout (KO) mice and TRPV4 KO mice. In metabolic cage experiments conducted under conscious conditions (i.e., voluntary voiding behavior), TRPV4 KO mice showed a markedly higher voiding frequency (VF; 19.3 ± 1.2 times/day) and a smaller urine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.