Article
Influence of genetic background and gender on bladder function in the mouse.
Autonomic neuroscience : basic & clinical - 1 Jun 2008
Cornelissen Laura L, Misajet Blake, Brooks David P, Hicks Alexandra
Abstract excerpt
Genetically targeted animals are used throughout research to investigate the role genes play in biological function, including the lower urinary tract. Generation of transgenic mice involves backcrossing for successive generations. Parental strain background genes can interact with the mutated gene potentially affecting interpretation of the mutant phenotype. Differences in physiological phenotypes may also be...
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