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Article

Overactive bladder phenotype induced by chronic activation of hypothalamic neuroendocrine stress pathways in rats with no extrinsic behavioral stress applied.

Scientific reports - 21 Dec 2025

Husain Jenan, Bakhareva Alexandra, Pace Anna, Noterman-Soulinthavong Maria, Herrera Gerald M, Erdos Benedek

Abstract excerpt

Overactive urinary bladder (OAB) negatively impacts quality of life, and stress is known to play a key role in its development. However, the mechanisms linking stress to OAB are not yet fully understood. This study examined how chronic activation of neuroendocrine stress pathways, independently of environmental or psychological stressors, affects bladder function and the control of micturition. Utilizing the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41422153
DOI: 10.1038/s41598-025-32428-6
PMCID: PMC12748808

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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