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Article

Different effects of GsMTx4 on nocturia associated with the circadian clock and Piezo1 expression in mice.

Life sciences - 1 Aug 2021

Ihara Tatsuya, Mitsui Takahiko, Shimura Hiroshi, Tsuchiya Sachiko, Kanda Mie, Kira Satoru, Nakagomi Hiroshi, Sawada Norifumi, Kamiyama Manabu, Shigetomi Eiji, Shinozaki Yoichi, Koizumi Schuichi, Takeda Masayuki

Abstract excerpt

OBJECTIVES: Nocturia is a major problem in geriatric patients. Clock genes regulate circadian bladder function and Piezo type mechanosensitive ion channel component 1 (Piezo1) that senses bladder fullness. We utilized WT and Clock mutant (ClockΔ19/Δ19: nocturia phenotype) mice to determine if the effects of GsMTx4, a Piezo1 inhibitor, is dependent on circadian Piezo1 expression in the bladder. METHODS: We...

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PMID: 33930366
DOI: 10.1016/j.lfs.2021.119555

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