Article
Lrrk2 R1628P variant is a risk factor for essential tremor.
Scientific reports - 12 Mar 2015
Chao Yin Xia, Ng Ebonne Yulin, Tan Louis, Prakash Kumar M, Au Wing-Lok, Zhao Yi, Tan Eng-King
Abstract excerpt
Essential tremor (ET) and Parkinson's disease (PD) are two of the most common adult onset movement disorders with overlapping clinical features. PD patients with leucine-rich repeat kinase-2 (LRRK2) mutations may present initially with an ET phenotype. To address the possibility of a common genetic link between ET and PD, we examined the association between a common LRRK2 R1628P gene variant and ET. The LRRK2...
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