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Association of LRRK2 R1628P variant with Parkinson's disease in Kinh Vietnamese: a cross-sectional study.

Neurogenetics - 31 Jul 2025

Do Minh Duc, Tran Tai Ngoc, Le Linh Hoang Gia, Mai Thao Phuong

Abstract excerpt

Parkinson's disease (PD) is a complex disorder with contributions by environmental and genetic factors. LRRK2 R1628P is a major genetic risk factor for developing PD in Asian populations. However, the effect of this variant in Kinh Vietnamese remains unclear. This study collected DNA samples of 832 subjects comprising 190 PD patients and 642 control cases, and the LRRK2 R1628P variant was genotyped using an...

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PMID: 40742407
DOI: 10.1007/s10048-025-00840-9

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