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Article

A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes.

Physiological genomics - 1 Jun 2015

Belalcazar L Maria, Papandonatos George D, McCaffery Jeanne M, Peter Inga, Pajewski Nicholas M, Erar Bahar, Allred Nicholette D, Balasubramanyam Ashok, Bowden Donald W, Brautbar Ariel, Pi-Sunyer F Xavier, Ballantyne Christie M, Huggins Gordon S

Abstract excerpt

Overweight/obese individuals with Type 2 diabetes have low adiponectin levels, which may improve with lifestyle changes. We investigated whether genetic variants associated with adiponectin levels in genome-wide association studies (GWAS) would also be related with adiponectin changes in response to an intensive lifestyle intervention (ILI), potentially through mechanisms altering the adipose microenvironment via...

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Share to Adiponectin
Share to Adiposity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diabetes Mellitus, Type 2

Share to Genetic Loci

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Share to Obesity

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Source

Open in PubMed Open full text

Identifiers

PMID: 25759378
DOI: 10.1152/physiolgenomics.00109.2014
PMCID: PMC4451387

Genes

CLDN7
ELP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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