Do genetic modifiers of high-density lipoprotein cholesterol and triglyceride levels also modify their response to a lifestyle intervention in the setting of obesity and type-2 diabetes mellitus?: The Action for Health in Diabetes (Look AHEAD) study.

doi:10.1161/CIRCGENETICS.113.000042

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Article

Do genetic modifiers of high-density lipoprotein cholesterol and triglyceride levels also modify their response to a lifestyle intervention in the setting of obesity and type-2 diabetes mellitus?: The Action for Health in Diabetes (Look AHEAD) study.

Circulation. Cardiovascular genetics - 1 Aug 2013

Huggins Gordon S, Papandonatos George D, Erar Bahar, Belalcazar L Maria, Brautbar Ariel, Ballantyne Christie, Kitabchi Abbas E, Wagenknecht Lynne E, Knowler William C, Pownall Henry J, Wing Rena R, Peter Inga, McCaffery Jeanne M

Abstract excerpt

BACKGROUND: High-density lipoprotein cholesterol (HDL-C) and triglycerides are cardiovascular risk factors susceptible to lifestyle behavior modification and genetics. We hypothesized that genetic variants identified by genome-wide association studies as associated with HDL-C or triglyceride levels modify 1-year treatment response to an intensive lifestyle intervention, relative to a usual care of diabetes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23861364
DOI: 10.1161/CIRCGENETICS.113.000042
PMCID: PMC4077278

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LIPC
CETP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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