Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues.

doi:10.1016/j.xgen.2025.100951

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Article

Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues.

Cell genomics - 10 Sept 2025

Wang Wenjing, Liew Wei Lin, Huang Shiqi, Chan Edmund, Tan Amelia Li Min, Tian Chi, Tong Yihan, Zhang Yuntian, Liu Fei, Qin Yixian, Ou Sean Jun Leong, Sadananthan Suresh Anand, Velan Sambasivam Sendhil, Venkataraman Kavita, Langley Sarah R, Enrico Petretto, Hoon Shawn, Tham Kwang Wei, Chong Yap Seng, Lee Yung Seng, Leow Melvin Khee-Shing, Sim Xueling, Khoo Chin Meng, Tai E Shyong, Khoo Eric Yin Hao, Liu Mei Hui, Liu Boxiang

Abstract excerpt

Weight loss through exercise and diet reduces the risk of type 2 diabetes, but the genetic regulation of gene expression and splicing in response to weight loss remains unclear in humans. We collected clinical data and skeletal muscle biopsies from 54 overweight/obese Asian individuals before and after a 16-week lifestyle intervention, which resulted in an average of ∼10% weight loss, accompanied by an ∼30%...

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Topics

Humans
Muscle, Skeletal
Exercise
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Weight Loss

Female

Middle Aged

Quantitative Trait Loci

Adult

Genome-Wide Association Study

Obesity

Gene Expression Regulation

Polymorphism, Single Nucleotide

Diet

Insulin Resistance

Source

Open in PubMed Open full text

Identifiers

PMID: 40683252
DOI: 10.1016/j.xgen.2025.100951
PMCID: PMC12534703

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