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Article

Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial.

Obesity (Silver Spring, Md.) - 1 Aug 2012

Peter Inga, McCaffery Jeanne M, Kelley-Hedgepeth Alyson, Hakonarson Hakon, Reis Steven, Wagenknecht Lynne E, Kopin Alan S, Huggins Gondon S

Abstract excerpt

The importance of lifestyle intervention for the prevention and treatment of type 2 diabetes (T2D) has been underscored by the limited benefit of pharmacologic therapies. We sought to determine whether genetic variants that contribute to T2D risk modify the response of weight and waist circumference to an intensive lifestyle intervention (ILI) in patients with obesity and T2D. Look AHEAD (Action for Health in...

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Source

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Identifiers

PMID: 22307069
DOI: 10.1038/oby.2012.11
PMCID: PMC3406235

Genes

JAZF1
IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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