Article
Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.
BMC medical genetics - 10 Jan 2011
Siitonen Niina, Pulkkinen Leena, Lindström Jaana, Kolehmainen Marjukka, Eriksson Johan G, Venojärvi Mika, Ilanne-Parikka Pirjo, Keinänen-Kiukaanniemi Sirkka, Tuomilehto Jaakko, Uusitupa Matti
Abstract excerpt
BACKGROUND: Adiponectin, secreted mainly by mature adipocytes, is a protein with insulin-sensitising and anti-atherogenic effects. Human adiponectin is encoded by the ADIPOQ gene on the chromosomal locus 3q27. Variations in ADIPOQ are associated with obesity, type 2 diabetes (T2DM) and related phenotypes in several populations. Our aim was to study the association of the ADIPOQ variations with body weight, serum...
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