Article
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
PLoS genetics - 1 Dec 2009
Richards J Brent, Waterworth Dawn, O'Rahilly Stephen, Hivert Marie-France, Loos Ruth J F, Perry John R B, Tanaka Toshiko, Timpson Nicholas John, Semple Robert K, Soranzo Nicole, Song Kijoung, Rocha Nuno, Grundberg Elin, Dupuis Josée, Florez Jose C, Langenberg Claudia, Prokopenko Inga, Saxena Richa, Sladek Robert, Aulchenko Yurii, Evans David, Waeber Gerard, Erdmann Jeanette, Burnett Mary-Susan, Sattar Naveed, Devaney Joseph, Willenborg Christina, Hingorani Aroon, Witteman Jaquelin C M, Vollenweider Peter, Glaser Beate, Hengstenberg Christian, Ferrucci Luigi, Melzer David, Stark Klaus, Deanfield John, Winogradow Janina, Grassl Martina, Hall Alistair S, Egan Josephine M, Thompson John R, Ricketts Sally L, König Inke R, Reinhard Wibke, Grundy Scott, Wichmann H-Erich, Barter Phil, Mahley Robert, Kesaniemi Y Antero, Rader Daniel J, Reilly Muredach P, Epstein Stephen E, Stewart Alexandre F R, Van Duijn Cornelia M, Schunkert Heribert, Burling Keith, Deloukas Panos, Pastinen Tomi, Samani Nilesh J, McPherson Ruth, Davey Smith George, Frayling Timothy M, Wareham Nicholas J, Meigs James B, Mooser Vincent, Spector Tim D
Abstract excerpt
The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n = 8,531) and sought validation of the lead single nucleotide polymorphisms (SNPs) in 5 additional cohorts (n = 6,202). Five SNPs were genome-wide significant in...
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