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Article

Control of Human Telomere Length by TRF1 and TRF2

1 Mar 2000

Abstract excerpt

Telomere length in human cells is controlled by a homeostasis mechanism that involves telomerase and the negative regulator of telomere length, TRF1 (TTAGGG repeat binding factor 1). Here we report that TRF2, a TRF1-related protein previously implicated in protection of chromosome ends, is a second negative regulator of telomere length. Overexpression of TRF2 results in the progressive shortening of telomere...

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Share to Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10669743
DOI: 10.1128/mcb.20.5.1659-1668.2000

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Control of Human Telomere Length by TRF1 and TRF2PMID 10669743Read ↗

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