Article
In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons.
Circulation. Cardiovascular genetics - 1 Jun 2015
Vaez Ahmad, Jansen Rick, Prins Bram P, Hottenga Jouke-Jan, de Geus Eco J C, Boomsma Dorret I, Penninx Brenda W J H, Nolte Ilja M, Snieder Harold, Alizadeh Behrooz Z
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWASs) have successfully identified several single nucleotide polymorphisms (SNPs) associated with serum levels of C-reactive protein (CRP). An important limitation of GWASs is that the identified variants merely flag the nearby genomic region and do not necessarily provide a direct link to the biological mechanisms underlying their corresponding phenotype. Here we...
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