Article
Myosin VI deafness mutation prevents the initiation of processive runs on actin.
Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2015
Pylypenko Olena, Song Lin, Shima Ai, Yang Zhaohui, Houdusse Anne M, Sweeney H Lee
Abstract excerpt
Mutations in the reverse-direction myosin, myosin VI, are associated with deafness in humans and mice. A myosin VI deafness mutation, D179Y, which is in the transducer of the motor, uncoupled the release of the ATP hydrolysis product, inorganic phosphate (Pi), from dependency on actin binding and...
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