Article
Myosin VI deafness mutation prevents the initiation of processive runs on actin.
Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2015
Pylypenko Olena, Song Lin, Shima Ai, Yang Zhaohui, Houdusse Anne M, Sweeney H Lee
Abstract excerpt
Mutations in the reverse-direction myosin, myosin VI, are associated with deafness in humans and mice. A myosin VI deafness mutation, D179Y, which is in the transducer of the motor, uncoupled the release of the ATP hydrolysis product, inorganic phosphate (Pi), from dependency on actin binding and destroyed the ability of single dimeric molecules to move processively on actin filaments. We observed that processive...
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