Article
Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin-NF-κB-HIF-1α pathway.
Oncotarget - 30 Mar 2015
Cao Lei, Fan Xiaoyu, Jing Wei, Liang Yingchao, Chen Rui, Liu Yingying, Zhu Minhui, Jia Rongjie, Wang Hao, Zhang Xueguang, Zhang Yanyun, Zhou Xuyu, Zhao Jian, Guo Yajun
Abstract excerpt
There is increasing evidence to suggest that hepatocellular carcinomas (HCCs) are sustained by a distinct subpopulation of self-renewing cells known as cancer stem cells. However, the precise signals required for maintenance of stemness-like properties of these cells are yet to be elucidated. Here, we demonstrated that the level of oncoprotein osteopontin (OPN) in tumor cells of the edge of bulk tumors was...
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