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Article

Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth.

Cell stem cell - 6 Mar 2014

Pietras Alexander, Katz Amanda M, Ekström Elin J, Wee Boyoung, Halliday John J, Pitter Kenneth L, Werbeck Jillian L, Amankulor Nduka M, Huse Jason T, Holland Eric C

Abstract excerpt

Stem-like glioma cells reside within a perivascular niche and display hallmark radiation resistance. An understanding of the mechanisms underlying these properties will be vital for the development of effective therapies. Here, we show that the stem cell marker CD44 promotes cancer stem cell phenotypes and radiation resistance. In a mouse model of glioma, Cd44(-/-) and Cd44(+/-) animals showed improved survival...

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Identifiers

PMID: 24607407
DOI: 10.1016/j.stem.2014.01.005
PMCID: PMC3999042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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