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Article

SOX9 is a novel cancer stem cell marker surrogated by osteopontin in human hepatocellular carcinoma.

Scientific reports - 26 Jul 2016

Kawai Takayuki, Yasuchika Kentaro, Ishii Takamichi, Miyauchi Yuya, Kojima Hidenobu, Yamaoka Ryoya, Katayama Hokahiro, Yoshitoshi Elena Yukie, Ogiso Satoshi, Kita Sadahiko, Yasuda Katsutaro, Fukumitsu Ken, Komori Junji, Hatano Etsuro, Kawaguchi Yoshiya, Uemoto Shinji

Abstract excerpt

The current lack of cancer stem cell (CSC) markers that are easily evaluated by blood samples prevents the establishment of new therapeutic strategies in hepatocellular carcinoma (HCC). Herein, we examined whether sex determining region Y-box 9 (SOX9) represents a new CSC marker, and whether osteopontin (OPN) can be used as a surrogate marker of SOX9 in HCC. In HCC cell lines transfected with a SOX9...

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Identifiers

PMID: 27457505
DOI: 10.1038/srep30489
PMCID: PMC4960550

Genes

SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SOX9 is a novel cancer stem cell marker surrogated by osteopontin in human hepatocellular carcinoma.PMID 27457505Read ↗

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