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Article

Osteopontin induces autophagy to promote chemo-resistance in human hepatocellular carcinoma cells.

Cancer letters - 28 Dec 2016

Liu Guoke, Fan Xiaoyu, Tang Min, Chen Rui, Wang Hao, Jia Rongjie, Zhou Xuyu, Jing Wei, Wang Huajing, Yang Yang, Yin Fan, Wei Huafeng, Li Bohua, Zhao Jian

Abstract excerpt

Hepatocellular carcinoma (HCC) is a major health burden worldwide for its high incidence and mortality. Osteopontin (OPN) is a chemokine-like, matricellular phosphoglycoprotein whose expression is elevated in various types of cancer including HCC. OPN has been shown to be involved in tumorigenesis, chemo-resistance, metastasis and sustaining stem-like properties of cancer cells. Autophagy is a cellular process by...

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PMID: 27702661
DOI: 10.1016/j.canlet.2016.09.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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