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Article

Interleukin-6/STAT3 Pathway Signaling Drives an Inflammatory Phenotype in Group A Ependymoma.

Cancer immunology research - 1 Oct 2015

Griesinger Andrea M, Josephson Rebecca J, Donson Andrew M, Mulcahy Levy Jean M, Amani Vladimir, Birks Diane K, Hoffman Lindsey M, Furtek Steffanie L, Reigan Phillip, Handler Michael H, Vibhakar Rajeev, Foreman Nicholas K

Abstract excerpt

Ependymoma (EPN) in childhood is a brain tumor with substantial mortality. Inflammatory response has been identified as a molecular signature of high-risk Group A EPN. To better understand the biology of this phenotype and aid therapeutic development, transcriptomic data from Group A and B EPN patient tumor samples, and additional malignant and normal brain data, were analyzed to identify the mechanism underlying...

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Source

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Identifiers

PMID: 25968456
DOI: 10.1158/2326-6066.CIR-15-0061
PMCID: PMC4596749

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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