Article
Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma.
Acta neuropathologica communications - 5 Apr 2020
Matsumoto Yuji, Ichikawa Tomotsugu, Kurozumi Kazuhiko, Otani Yoshihiro, Fujimura Atsushi, Fujii Kentaro, Tomita Yusuke, Hattori Yasuhiko, Uneda Atsuhito, Tsuboi Nobushige, Kaneda Keisuke, Makino Keigo, Date Isao
Abstract excerpt
Glioblastoma (GBM) is characterized by extensive tumor cell invasion, angiogenesis, and proliferation. We previously established subclones of GBM cells with distinct invasive phenotypes and identified annexin A2 (ANXA2) as an activator of angiogenesis and perivascular invasion. Here, we further explored the role of ANXA2 in regulating phenotypic transition in GBM. We identified oncostatin M receptor (OSMR) as a...
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