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Article

Impact of Tat Genetic Variation on HIV-1 Disease

1 Jan 2012

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) promoter or long-terminal repeat (LTR) regulates viral gene expression by interacting with multiple viral and host factors. The viral transactivator protein Tat plays an important role in transcriptional activation of HIV-1 gene expression. Functional domains of Tat and its interaction with transactivation response element RNA and cellular transcription factors have...

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PMID: 22899925
DOI: 10.1155/2012/123605

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