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Article

A naturally occurring substitution in human immunodeficiency virus Tat increases expression of the viral genome.

Journal of virology - 1 Aug 2003

Reza Syed M, Shen Lin-Ming, Mukhopadhyay Rupa, Rosetti Mihaela, Pe'ery Tsafi, Mathews Michael B

Abstract excerpt

A natural amino acid substitution in the human immunodeficiency virus type 1 (HIV-1) transcriptional activator Tat increases its activity and compensates for deleterious mutations elsewhere in the Tat protein. Substitution of asparagine for threonine 23 increases Tat transactivation of the HIV-1 promoter and the binding of Tat to the cellular kinase positive transcription elongation factor b (P-TEFb). Of nine...

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Identifiers

PMID: 12857933
DOI: 10.1128/jvi.77.15.8602-8606.2003
PMCID: PMC165250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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