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Article

Frequency and allele burden of CALR mutations in Chinese with essential thrombocythemia and primary myelofibrosis without JAK2(V617F) or MPL mutations.

Leukemia research - 1 May 2015

Li Ning, Yao Qiu-Mei, Gale Robert Peter, Li Jin-Lan, Li Ling-Di, Zhao Xiao-Su, Jiang Hao, Jiang Qian, Jiang Bin, Shi Hong-Xia, Chen Shan-Shan, Liu Kai-Yan, Huang Xiao-Jun, Ruan Guo-Rui

Abstract excerpt

CALR mutations are detected in about 50% of persons of predominately European descent with essential thrombocythemia (ET) or primary myelofibrosis (PMF) with wild-type alleles of JAK2 and MPL. We studied 1088 Chinese with diverse myeloproliferative neoplasms including ET (N=234) and PMF (N=50) without JAK2(V617F) or MPL exon 10 mutations. CALR mutation was detected in 53% (95% CI, 46-60%) of subjects with ET and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25746303
DOI: 10.1016/j.leukres.2015.02.006

Genes

CALR
JAK2
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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