Article
Frequencies, Laboratory Features, and Granulocyte Activation in Chinese Patients with CALR-Mutated Myeloproliferative Neoplasms.
PloS one - 1 Jan 2015
Guo Haixiu, Chen Xiuhua, Tian Ruiyuan, Chang Jianmei, Li Jianlan, Tan Yanhong, Xu Zhifang, Ren Fanggang, Zhao Junxia, Pan Jie, Zhang Na, Wang Xiaojuan, He Jianxia, Yang Wanfang, Wang Hongwei
Abstract excerpt
Somatic mutations in the CALR gene have been recently identified as acquired alterations in myeloproliferative neoplasms (MPNs). In this study, we evaluated mutation frequencies, laboratory features, and granulocyte activation in Chinese patients with MPNs. A combination of qualitative allele-specific polymerase chain reaction and Sanger sequencing was used to detect three driver mutations (i.e., CALR, JAK2V617F,...
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