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Article

CALR mutation burden in essential thrombocythemia and disease outcome.

Blood - 28 Mar 2024

Guglielmelli Paola, Szuber Natasha, Gangat Naseema, Capecchi Giulio, Maccari Chiara, Harnois Michaël, Karrar Omer, Abdelmagid Maymona, Balliu Manjola, Nacca Elena, Atanasio Alessandro, Sestini Ilaria, Désilets Audrey, Loscocco Giuseppe Gaetano, Rotunno Giada, Busque Lambert, Tefferi Ayalew, Vannucchi Alessandro Maria

Abstract excerpt

ABSTRACT: Among 281 patients with essential thrombocythemia and calreticulin (CALR) mutation, we found a variant allele frequency of ≥60% to be associated with significantly shortened myelofibrosis-free survival, mostly apparent with CALR type-1 and CALR type-indeterminate mutations.

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Identifiers

PMID: 38252902
DOI: 10.1182/blood.2023023428

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