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Article

Altered nociception in mice with genetically induced hypoglutamatergic tone.

Neuroscience - 7 May 2015

Kayser V, Viguier F, Melfort M, Bourgoin S, Hamon M, Masson J

Abstract excerpt

Extensive pharmacological evidence supports the idea that glutamate plays a key role in both acute and chronic pain. In the present study, we investigated the implication of the excitatory amino acid in physiological nociception by using mutant mice deficient in phosphate-activated glutaminase type 1 (GLS1), the enzyme that synthesizes glutamate in central glutamatergic neurons. Because homozygous GLS1-/- mutants...

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Identifiers

PMID: 25743253
DOI: 10.1016/j.neuroscience.2015.02.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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