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Article

Gene knockout of glycine transporter 1: characterization of the behavioral phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2004

Tsai Guochuan, Ralph-Williams Rebecca J, Martina Marzia, Bergeron Richard, Berger-Sweeney Joanne, Dunham Kevin S, Jiang Zhichun, Caine S Barak, Coyle Joseph T

Abstract excerpt

N-methyl-d-aspartate receptor (NMDAR) activation requires both the binding of glutamate to its recognition site and occupancy of the strychnine insensitive glycine modulatory site (GMS). Pharmacological studies suggest that the glycine transporter, GlyT1, maintains subsaturating concentrations of glycine at synaptic NMDARs. To characterize further the role of GlyT1, we generated mice in which the gene encoding...

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Identifiers

PMID: 15159536
DOI: 10.1073/pnas.0402662101
PMCID: PMC420420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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