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Article

Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate.

Journal of neurochemistry - 1 Oct 2002

Bacich Dean J, Ramadan Epolia, O'Keefe Denise S, Bukhari Noreen, Wegorzewska Iga, Ojeifo Olumide, Olszewski Rafal, Wrenn Craige C, Bzdega Tomasz, Wroblewska Barbara, Heston Warren D W, Neale Joseph H

Abstract excerpt

Glutamate carboxypeptidase II (GCPII, EC 3.14.17.21) is a membrane-bound enzyme found on the extracellular face ofglia. The gene for this enzyme is designated FOLH1 in humans and Folh1 in mice. This enzyme has been proposed to be responsible for inactivation of the neurotransmitter N-acetylaspartylglutamate (NAAG) following synaptic release. Mice harboring a disruption of the gene for GCPII/Folh1 were generated...

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Identifiers

PMID: 12358725
DOI: 10.1046/j.1471-4159.2002.01117.x

Genes

FOLH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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