Article
Disruption of Th2a and Th2b genes causes defects in spermatogenesis.
Development (Cambridge, England) - 1 Apr 2015
Shinagawa Toshie, Huynh Linh My, Takagi Tsuyoshi, Tsukamoto Daisuke, Tomaru Chinatsu, Kwak Ho-Geun, Dohmae Naoshi, Noguchi Junko, Ishii Shunsuke
Abstract excerpt
The variant histones TH2A and TH2B are abundant in the testis, but their roles in spermatogenesis remain elusive. Here, we show that male mutant mice lacking both Th2a and Th2b genes were sterile, with few sperm in the epididymis. In the mutant testis, the lack of TH2B was compensated for by overexpression of H2B, whereas overexpression of H2A was not observed, indicating a decrease in the total histone level....
Topics
- Animals
- Cell Cycle Proteins
- Chromatin
- Chromosomal Proteins, Non-Histone
- Chromosomes, Mammalian
- DNA-Binding Proteins
- Female
- Gene Deletion
- Histones
- Male
- Meiosis
- Mice, Inbred BALB C
- Mutation
- Nuclear Proteins